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Join the leading VHL researchers, physicians, and experts in Milan!

What: The 16th International VHL Medical Symposium, hosted by the VHL Alliance and the San Raffaele Scientific Institute, will bring scientists, clinicians and advocates together for two days of collaboration, idea exchange, and thought leadership.

 

Where: Congress Centre HSR / Via Olgettina 58 – Milano, Italy

 

When: October 19-20, 2024

 

Registration Fee: Standard $175 / Residents $100 / Students $25 / VHL Patient Advocates $75 / Corporate $750. Click here to register.

 

Lodging: Hotel Raffaele Via Olgettina, 60, 20132 Milano MI, Italy

 

SCIENTIFIC COORDINATOR:

Dr. Alessandro Larcher, Milan (Italy)

 

SCIENTIFIC COMMITTEE:

Dr. Ruhee Dere, Huston – TX (USA)

Dr. Othon Iliopoulos, Boston – MA (USA)

Prof. Andrea Salonia, Milan (Italy)

 

ORGANIZING COMMITTEE:

Joshua Mann, Boston – MA (USA)

Janet Thompson, Boston – MA (USA)

 

Abstract Submission Details

The deadline for abstract submissions is July 3rd. A link to submit abstracts will be provided to event attendees by email following the registration process. Please note that there is a 400 word maximum for abstract submissions. 

  
Day 1 – 19.10.2024
8:30 – 9Registration 
9 – 9:05Welcome and IntroductionA. Larcher (IT), A. Salonia (IT), O. Iliopoulos (US), J. Thompson (US)
9:05 – 9:10Opening Remarks
K. Rathmell (US)
 Session 1 – Special Lecture 
9:10-9:30Belzutifan Development: Intrinsic and Acquired ResistanceJ. Brugarolas (US)
 Session 2 – Clinical management of VHL tumors – surveillance, diagnosis, and treatmentR. van Leeuwaarde (NL) Andrea Veltri (IT)
9:30 – 9:50Recommendations for management of VHL-related pancreatic manifestationsA. Tirosh (IL)
9:50 – 10:10Identification, surveillance and treatment for VHL-related pheochromocytomas and paragangliomasK. Pacak (US)
10:10 – 10:30Proffered Abstract – Distinct genomic and immune profiles of kidney cysts and clear cell renal cell carcinomas in von Hippel-Lindau syndromeFrancesca Corea
10:30 – 10:50Coffee Break 
10:50 – 11:10Radiation therapy in ccRCC: potential application in VHL diseaseR. van Leeuwaarde (NL)
11:10 – 11:30Systematic assessment of surgical outcomes in hereditary ccRCCA. Larcher (IT)
11:30 – 11:50Proffered Abstract – Germline VHL-gene alterations are associated with increased risk of cardiovascular disease – al large population studyReut Halperin
 Session 3 – Exploring the Molecular Basis of VHL disease – Genetics of VHLModerators:
P. Carrera (IT)
11:50 – 12:10Modeling the von Hippel Lindau disease by using hIPSCB. Gardie (FR)
12:10 – 12:30Hypoxic stress favors somatic mutation in pre-cancer renal cellsI. Franco (IT)
12:30 – 12:50Genetic analysis of VHL-related ccRCCS. Gad (Fr)
12:50 – 1:10Proffered Abstract – Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinomaXin Lu
1:10 – 2:20Lunch / Poster Session 1 
 Session 5 – Exploring the Molecular Basis of VHL disease – Tumor heterogeneity in VHL ccRCCR. Bernardi (IT) Ian Frew
2:20 – 2:40Influence of the tumour microenvironment and somatic mutations on tumour growthT.J. Mitchell (UK)
2:40 – 3:00Distinct transcriptomic and genomic profiles of kidney cysts and clear cell renal cell carcinomas in Von Hippel-Lindau diseaseI. Rowe (IT)
3:00 – 3:20VHL disease: repeated clonal evolution in a lifetimeS. Turajilic (UK)
3:20 – 3:40Proffered Abstract – Kdm5c mutation cooperates with Vhl and Pbrm1 mutations to induce ccRCC in miceFrancesca Cuomo
3:40 – 4:00Coffee Break 
 Session 6 – Clinical management of VHL tumors – Live Tumor BoardO. Iliopoulos (US), E. Jonasch (US), A. Tirosh (IL), F. De Cobelli (IT), S. Mukai (US)
4:00 – 4:30Case Presentation of VHL Disease 1 
4:30 – 5:00Case Presentation of VHL Disease 2Junior Physician
5:00 – 5:10Closing RemarksA. Larcher (IT), A. Salonia (IT), O. Iliopoulos (US)
   
Day 2 – 20.10.2024
8:25 – 8:30Welcome and IntroductionA. Larcher (IT), A. Salonia (IT), O. Iliopoulos (US)
 Session 1 – Special Lecture 
8:30 – 9:10VHL 1984-2024: Evolution of Diagnosis, Management, Surgery and TherapyM. Linehan (US)
 Session 2 – Clinical management of VHL tumors – Systemic Agents for VHL
Moderators: Necchi
9:10 – 9:30Mid-term outcomes following HIF inhibition in VHL diseaseE. Jonasch (US)
9:30 – 9:50Quality of life and toxicity under HIF inhibitors in hereditary and sporadic ccRCCSrinivasan
9:50 – 10:10Impact of HIF-2a Inhibition on CNS tumorsO. Iliopoulos
10:10 – 10:30Coffee Break 
 Session 3 – Signal Transduction and Modeling in VHL DiseaseModerators:
A. Boletta (IT), R. Srinivasan (US)
10:30 – 10:50Study New VHL Signaling Axis in Kidney CancerQ. Zhang
10:50 – 11:10Linking VHL and SETD2 in a Common Oncogenic Pathway Converging at the Mitotic Spindle.R. Dere
11:10 – 11:30Transcriptional Control of Renal CarcinogenesisS. Vanharanta
11:30 – 11:50Cross Species Functionalization Of The Cancer Genome
G. Genovese (US)
11:50 – 12:10Sex-specific differences in ccRCC: separating the functions of KDM5C and KDM5DI. Frew
12:10 – 12:30Proffered Abstract – Oncostatin M reshapes the tumor microenvironment during ccRCC development by inducing epigenetic changes in endothelial cells
Hieu-Huy Nguyen-Tran
12:30 – 1:50Lunch / Poster Session 2 
 Session 4 – Clinical management of VHL tumors – Extrarenal PrimariesModerators:
A. Tirosh (IL), M. Falconi/S.Partelli (IT)
1:50 – 2:10Minimally invasive treatment of retinal hemangioblastomaS. Mukai (US)
2:10 – 2:30CNS Hemangioblastomas – the role of surgery in the modern era
P. Chittiboina (US)
2:30 – 2:50CNS hemangioblastoma – the reasons for surgery upfrontA Feletti (IT)
2:50 – 3:10Optimizing surgical outcomes for hereditary pancreatic NETN. Nilubol (US)
3:10 – 3:30Proffered Abstract – Developing Prophylactic and Therapeutic Gene Therapy for von Hippel-Lindau Syndrome Using Adeno-Associated VectorsPedram Moeini
3:30 – 3:50Coffee Break 
 Session 5 – Patient associations and policymakingModerators:
J. Mann (US), R. Giles (NL)
3:50 – 4:10Addressing the Psychosocial Needs of Individuals living with VHLG. Perez (US)
4:10 – 4:30Current unmet need of European VHL FamiliesR. Giles (NL)
4:30 – 4:45State of VHLAJ. Thompson (US)
4:45 – 5:00Closing RemarksA. Larcher (IT), A. Salonia (IT), O. Iliopoulos (US)

MILANO
Milan is a vibrant and exciting city that offers a wealth of experiences for everyone. It is home to some of the most renowned museums and galleries in the world, including the Last Supper Fresco, the Pinacoteca di Brera and the Leonardo da Vinci Museum, but also of iconic landmarks such as the Gothic-style Duomo di Milano and the imposing Sforza Castle. Milan is not only the capital of Italian fashion but also a foodie’s paradise, offering a diverse range of culinary experiences that showcase the best of Italian cuisine. Visitors can enjoy everything from traditional street food to Michelin-starred fine dining. No matter the day or the time, Milano is alive: music festivals, art exhibitions, theatrical performances and much
more are there to entertain any kind of guest.

 

CONGRESS VENUE
Congress Centre HSR
Via Olgettina 58/60 – Milano
Building Dibit 1

 

The San Raffaele Research Hospital is a highly specialized multi-disciplinary medical center of world importance, which embodies the integrity of the treatment, clinical research and teaching activities. San
Raffaele provides treatment in all existing medical fields, which allows this center to take care of the most
complex patient cases. The Hospital is recognized as IRCCS (Scientific Institute for Research and Healthcare) for its research in molecular medicine and innovative treatments application, such as the gene therapy.

The hospital is a multi-specialty center with more than 50 clinical specialties available and with over 1600 beds; it is accredited by the Italian National Health System to provide care to both public and private, Italian and international patients. 

 

In 2018 the San Raffaele Hospital performed over 51,000 patient admissions, 72,000 emergency room encounters and delivered over 1.5 million outpatient medical services. It is widely regarded as the most celebrated hospital in the country and among the most reputable medical centers in Europe. San Raffaele’s wards and operating theatres are equipped with the most advanced machines, such as PET, PET/CT, Gamma Knife, Cyber Knife, Rapid Arc, Tomotherapy. San Raffaele’s Radiotherapy Unit was the first place in Europe to install Tomotherapy in 2004. Nowadays this Unit confirms to be one of the most experienced worldwide; it has developed numerous protocols for cancer treatment of the prostate, breast,
central nervous system, brain, liver, pancreas, gastrointestinal tract, lungs, and others. The Oncological
Board of the Hospital consisting of diagnosticians, clinical oncologists, immunologists, surgeons and
radiotherapists, hold weekly meetings to discuss oncological patients’ pathways in a multidisciplinary manner.

Beside its Cancer Center, San Raffaele is well-known for its medical know-how in cardiology and cardiac surgery, neurology and neurosurgery, gastroenterology and gastrointestinal tract surgery, liver surgery, pancreas surgery, transplant medicine, gynecology and obstetrics, urology, dermatology, ophthalmology, immunology, rheumatology and pediatrics.

San Raffaele is a pioneer in the field of gene medicine and treatment of rare immunologic and genetic diseases. San Raffaele Scientific Institute is where the first in the world gene therapy with stem cells was created, named Strimvelis, for patients affected by ADA-SCID syndrome.

 

The Research at the San Raffaele Hospital focuses on integrating basic, translational and clinical research to provide the most advanced care to the patients. It counts on over 1,500 scientists, working in state-of-the-art facilities covering a surface of 130,000 square meters, and have produced over 1,446 scientific publications in 2018.

Research at San Raffaele aims at understanding the mechanisms underlying a variety of important human diseases and at identifying new targets and new therapeutic strategies to treat them.

 

The San Raffaele Hospital hosts the Università Vita-Salute San Raffaele, a fully private university with a
complete Medical School (including specialty courses and residencies), Nursing School, a Psychology graduate and post-graduate programs, and Allied Health Professions School. The mission of the Vita-Salute

San Raffaele University is to answer the question “Quid est homo?” in the belief that the human being is a biological, psychological and spiritual unicum. Since 2010 the San Raffaele Hospital also hosts the
International MD Program, the only graduate program accredited to license Medical Doctors in both Europe and North America.

 

Accessibility
Metro 2 (Green LINE) from city centre to Cascina Gobba stop
From Cascina Gobba there is a private train line that will bring to HSR in 5 minutes

 

 

VISA REQUIREMENTS
Depending on your citizenship, you may need to obtain a VISA before coming to Italy. For detailed
information, visit the website of the Italian Ministry of Foreign Affairs: http://vistoperitalia.esteri.it/home/en
It is the delegate’s responsibility to investigate the VISA requirements for Italy and to apply for a VISA, if
necessary.

 

The conference organizers and/or the Organizing Secretariat will not directly contact embassies and
consulates on behalf of VISA applicants.

 

Visas should be requested at least 2 months before departure, you can apply also later but it is not sure it will be released on time, as the application process can take several weeks.

 

Special information and questions for VISA can be requested to the Congress Secretariat at the e-mail
address: [email protected].

 

INVITATION LETTER
The invitation letter to the conference can be requested to the Congress Secretariat after the registration is paid and accepted.

 

Please contact us at: [email protected] Please note that the standard invitation letter of the conference may NOT be suitable for VISA application of those countries with special dedicated procedures.

Please check your status and action requested to you as explained in the Visa Information Area.

 

SUGGESTED ACCOMMODATION
Hotel Rafael ***
Via Olgettina, 60 – 20132 Milano
Email: [email protected]
https://www.rafaelhotel.it/
Located near the Conference venue

Hotel NH Milano 2 ****
Strada di Olgia Nuova – 20090 Segrate Milano
Email: [email protected]
Website

15/20 min walking distance from the venue

 

HOW TO REACH MILAN
RAILWAY STATION

Stazione Centrale
It is the second largest and second busiest station in Italy, located 3 km away from the Duomo and is connected by 2 metro lines (M3 yellow and M2 green). The imposing and majestic railway station is a crucial hub for the city’s services and shopping district and the main departure point for the High-Speed train and rail connections
with the rest of Europe.

 

MALPENSA AIRPORT
The most important intercontinental hub in Southern Europe, located just at about 50 km from Milan
city center and quickly reachable by car, train (high-speed Malpensa Express train), bus or taxi.
Malpensa airport is in a strategic position in the financial and productive heart of Europe. It is located just over 50 kilometres from Milan and is quickly reachable by car, train, bus or taxi. It is one of the most important airports in Europe, offering more than 2,500 direct flights each week and numerous intercontinental and long-
haul destinations. It is also the leading Italian airport in terms of freight transport.

 

FROM/TO MALPENSA AIRPORT
Malpensa Express Train: the airport can be easily reached from the center of Milan with the Malpensa Express train from Milan Cadorna, Milan Centrale, and Milan Porta Garibaldi stations. Malpensa Express train stops at Malpensa Terminals 1 and 2. Trains scheduled every 30 minutes. Travel Time: Cadorna (43 minutes) – Central
Station (53 min) – Porta Garibaldi (41 minutes)

By Coach: bus connections between Milan Central Station and the two terminals of Malpensa Airport are
operated by three bus lines: Terravision, Malpensa Bus Express (Autostradale) and Malpensa Shuttle (Air
Pullman). Average travel time: 45 minutes

By car: Milan Malpensa airport is easily reachable by car using the A8 / A9 motorway if you are coming from
Milan or located to the North and East of the airport, the A4 motorway if you are coming from the West or the
South.

By taxi: various radiotaxi services are available at both Milan Malpensa Airport Terminals. The taxi ranks are
located at the ARRIVALS, at the ground floor, at gate 6 of Terminal 1 and at gate 4 at Terminal 2. Fixed taxi fare
from/to Malpensa to/from Milan: 110 €

 

LINATE AIRPORT
The city airport is located 7 km from downtown and quickly reachable by car, metro, bus or taxi.
Milan Linate Airport is the second-largest airport serving the city and is an inner-city airport, located just 7 km from central Milan.

 

FROM/TO LINATE AIRPORT
By Metro: the M4 blue line connects Linate airport to the city center.

By Train: it is possible to reach Milan Linate airport by train arriving at the Milan Forlanini station, directly connected to the airport through the urban bus line 73 (7 stops for a journey of about 10 minutes).

By Coach: the bus connections between the city of Milan and the neighboring municipalities and Linate Airport are operated by various bus lines: ATM, Airbus, Starfly, Autoguidovie, and Air Pullman. Travel time: to/from
Milan City Centre (Duomo): 60 minutes – to/from Milan Central Station: 25 minutes

By Car: Milan Linate airport can be easily reached by car from the North (A4/A51), from the West (Viale
Forlanini) and from the East (A35-Brebemi) via the Rivoltana provincial road.

By Taxi: several radiotaxi services are available at Milan Linate. The taxi ranks are located at the ARRIVALS, at the ground floor.

 

MILAN BERGAMO AIRPORT (ORIO AL SERIO)
Low-cost companies’ airport located at 45 km north-east of Milan and easy reachable by car (A4), by
bus or taxi.

 

Milan Bergamo Airport is the third busiest international airport in Italy. The airport is 45 km north-east of Milan and is mainly operated by low cost companies.

 

FROM/TO MILAN BERGAMO AIRPORT
By Train: you can arrive by train to Bergamo train station and use the convenient bus service ATB which in just
10 minutes will bring you to Milan Bergamo airport (departures every 15 minutes).

By Coach: the bus connections to the centre of Milan are operated by different bus companies: Terravision,
Autostradale, Orio Shuttle, Flixbus. Travel time to Milan Central Station: 50 minutes.

By car: for those coming on the A4 from Milan it is recommended to exit at Bergamo and follow for Milan Bergamo Airport. For those coming on the A4 from Brescia, the recommended exit is Seriate.

Taxi: at the arrivals exit you will find the taxi zone (110/130 €).